Mycobacterium tuberculosis Invasion of the Human Lung: First Contact.

ABSTRACT: Early immune responses to Mycobacterium tuberculosis (Mtb) invasion of the human lung play a decisive role in the outcome of infection, leading to either rapid clearance of the pathogen or stable infection. Despite their critical impact on health and disease, these early host-pathogen interactions at the primary site of infection are still poorly understood. In vitro studies cannot fully reflect the complexity of the lung architecture and its impact on host-pathogen interactions, while animal models have their own limitations. In this study, we have investigated the initial responses in human lung tissue explants to Mtb infection, focusing primarily on gene expression patterns in different tissue-resident cell types. As first cell types confronted with pathogens invading the

SUBMITTER: Maertzdorf J 

PROVIDER: S-EPMC6022014 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature