Exercise training as S-Klotho protein stimulator in sedentary healthy adults: Rationale, design, and methodology.

ABSTRACT:

Aims

The secreted form of the α-Klotho gene (S-Klotho), which is considered a powerful biomarker of longevity, makes it an attractive target as an anti-ageing therapy against functional decline, sarcopenic obesity, metabolic and cardiovascular diseases, osteoporosis, and neurodegenerative disorders. The S-Klotho plasma levels could be related to physical exercise inasmuch physical exercise is involved in physiological pathways that regulate the S-Klotho plasma levels. FIT-AGEING will determine the effect of different training modalities on the S-Klotho plasma levels (primary outcome) in sedentary healthy adults. FIT-AGEING will also investigate the physiological consequences of activating the klotho gene (secondary outcomes).

Methods

FIT-AGEING will recruit 80 sedentary, hea

SUBMITTER: Amaro-Gahete FJ 

PROVIDER: S-EPMC6022251 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature