Serum Folate Correlates with Severity of Guillain-Barre Syndrome and Predicts Disease Progression.

ABSTRACT: The aim of this study was to determine the associations between serum folate level and the clinical course and severity of Guillain-Barré syndrome (GBS). We retrospectively enrolled 112 pairs of GBS patients and age- and sex-matched healthy controls with measured serum folate levels. On admission, 21 (18.9%) GBS patients had folate deficiency, of which only two were female patients. Patients with normal folate levels had a shorter disease progression than those with folate deficiency (median progression duration: 6 versus 13 days, p < 0.001). Serum folate levels on admission were correlated with progression duration and Medical Research Council (MRC) sum score in the upper limbs at nadir (r = -0.261, p = 0.005; r = -0.208, p = 0.03) but not with the duration of hospita

SUBMITTER: Gao Y 

PROVIDER: S-EPMC6022270 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature