LPG: A four-group probabilistic approach to leveraging pleiotropy in genome-wide association studies.

ABSTRACT:

Background

To date, genome-wide association studies (GWAS) have successfully identified tens of thousands of genetic variants among a variety of traits/diseases, shedding light on the genetic architecture of complex disease. The polygenicity of complex diseases is a widely accepted phenomenon through which a vast number of risk variants, each with a modest individual effect, collectively contribute to the heritability of complex diseases. This imposes a major challenge on fully characterizing the genetic bases of complex diseases. An immediate implication of polygenicity is that a much larger sample size is required to detect individual risk variants with weak/moderate effects. Meanwhile, accumulating evidence suggests that different complex diseases can share genetic risk variants

SUBMITTER: Yang Y 

PROVIDER: S-EPMC6022345 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature