Kinetic Insights into Hydrogen Sulfide Delivery from Caged-Carbonyl Sulfide Isomeric Donor Platforms.

ABSTRACT: Hydrogen sulfide (H₂S) is a biologically important small gaseous molecule that exhibits promising protective effects against a variety of physiological and pathological processes. To investigate the expanding roles of H₂S in biology, researchers often use H₂S donors to mimic enzymatic H₂S synthesis or to provide increased H₂S levels under specific circumstances. Aligned with the need for new broad and easily modifiable platforms for H₂S donation, we report here the preparation and H₂S release kinetics from a series of isomeric caged-carbonyl sulfide (COS) compounds, including thiocarbamates, thiocarbonates, and dithiocarbonates, all of which release COS that is quickly converted to H₂S by the ubiquitous

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC6022369 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature