Synaptic aging disrupts synaptic morphology and function in cerebellar Purkinje cells.

ABSTRACT: Synapses are key structures in neural networks, and are involved in learning and memory in the central nervous system. Investigating synaptogenesis and synaptic aging is important in understanding neural development and neural degeneration in diseases such as Alzheimer disease and Parkinson's disease. Our previous study found that synaptogenesis and synaptic maturation were harmonized with brain development and maturation. However, synaptic damage and loss in the aging cerebellum are not well understood. This study was designed to investigate the occurrence of synaptic aging in the cerebellum by observing the ultrastructural changes of dendritic spines and synapses in cerebellar Purkinje cells of aging mice. Immunocytochemistry, DiI diolistic assays, and transmission electron microscopy we

SUBMITTER: Fan WJ 

PROVIDER: S-EPMC6022458 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature