Retinoid X receptor α downregulation is required for tail and caudal spinal cord regeneration in the adult newt.

ABSTRACT: Some adult vertebrate species, such as newts, axolotls and zebrafish, have the ability to regenerate their central nervous system (CNS). However, the factors that establish a permissive CNS environment for correct morphological and functional regeneration in these species are not well understood. Recent evidence supports a role for retinoid signaling in the intrinsic ability of neurons, in these regeneration-competent species, to regrow after CNS injury. Previously, we demonstrated that a specific retinoic acid receptor (RAR) subtype, RARβ, mediates the effects of endogenous retinoic acid (RA) on neuronal growth and guidance in the adult newt CNS after injury. Here, we now examine the expression of the retinoid X receptor RXRα (a potential heterodimeric transcriptional regulator with RARβ)

SUBMITTER: Walker SE 

PROVIDER: S-EPMC6022477 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature