Prognostic value of localization of epidermal growth factor receptor in lung adenocarcinoma.

ABSTRACT:

Background

The nuclear translocation of epidermal growth factor receptor (EGFR) has been considered to play a role in carcinogenesis. However, the relevance of differentially located EGFR proteins in lung cancer remains unclear.

Methods

We examined 161 patients with primary lung adenocarcinoma to detect EGFR expression in lung cancer cells using immunohistochemistry and determined the correlations of EGFR expression with clinical characteristics, EGFR mutations, and survival time. Moreover, we graded complete membranous staining with strong intensity as high membranous EGFR (mEGFR) expression, and nuclear EGFR staining with strong intensity as high nuclear (nEGFR) expression.

Results

The prevalence of high mEGFR and nEGFR expression in lung adenocarcinoma was 42.86 an

SUBMITTER: Wang JL 

PROVIDER: S-EPMC6022489 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature