Comparison of village dog and wolf genomes highlights the role of the neural crest in dog domestication.

ABSTRACT:

Background

Domesticated from gray wolves between 10 and 40 kya in Eurasia, dogs display a vast array of phenotypes that differ from their ancestors, yet mirror other domesticated animal species, a phenomenon known as the domestication syndrome. Here, we use signatures persisting in dog genomes to identify genes and pathways possibly altered by the selective pressures of domestication.

Results

Whole-genome SNP analyses of 43 globally distributed village dogs and 10 wolves differentiated signatures resulting from domestication rather than breed formation. We identified 246 candidate domestication regions containing 10.8 Mb of genome sequence and 429 genes. The regions share haplotypes with ancient dogs, suggesting that the detected signals are not the result of recent selectio

SUBMITTER: Pendleton AL 

PROVIDER: S-EPMC6022502 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature