Association of reproductive history with breast tissue characteristics and receptor status in the normal breast.

ABSTRACT: INTRODUCTION:Reproductive history has been associated with breast cancer risk, but more knowledge of the underlying biological mechanisms is needed. Because of limited data on normal breast tissue from healthy women, we examined associations of reproductive history and established breast cancer risk factors with breast tissue composition and markers of hormone receptors and proliferation in a nested study within the Karolinska Mammography project for risk prediction for breast cancer (Karma). MATERIALS AND METHODS:Tissues from 153 women were obtained by ultrasound-guided core needle biopsy as part of the Karma project. Immunohistochemical staining was used to assessed histological composition of epithelial, stromal and adipose tissue, epithelial and stromal oestrogen receptor (ER) and prog

SUBMITTER: Gabrielson M 

PROVIDER: S-EPMC6022521 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature