Physiological mechanisms of thalamic ventral intermediate nucleus stimulation for tremor suppression.

ABSTRACT: Ventral intermediate thalamic deep brain stimulation is a standard therapy for the treatment of medically refractory essential tremor and tremor-dominant Parkinson's disease. Despite the therapeutic benefits, the mechanisms of action are varied and complex, and the pathophysiology and genesis of tremor remain unsubstantiated. This intraoperative study investigated the effects of high frequency microstimulation on both neuronal firing and tremor suppression simultaneously. In each of nine essential tremor and two Parkinson's disease patients who underwent stereotactic neurosurgery, two closely spaced (600 µm) microelectrodes were advanced into the ventral intermediate nucleus. One microelectrode recorded action potential firing while the adjacent electrode delivered stimulation trains at 10

SUBMITTER: Milosevic L 

PROVIDER: S-EPMC6022553 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature