Classifying tumors by supervised network propagation.

ABSTRACT:

Motivation

Network propagation has been widely used to aggregate and amplify the effects of tumor mutations using knowledge of molecular interaction networks. However, propagating mutations through interactions irrelevant to cancer leads to erosion of pathway signals and complicates the identification of cancer subtypes.

Results

To address this problem we introduce a propagation algorithm, Network-Based Supervised Stratification (NBS2), which learns the mutated subnetworks underlying tumor subtypes using a supervised approach. Given an annotated molecular network and reference tumor mutation profiles for which subtypes have been predefined, NBS2 is trained by adjusting the weights on interaction features such that network propagation best recovers the provided subtypes. Afte

SUBMITTER: Zhang W 

PROVIDER: S-EPMC6022559 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature