Inhibition of Mitochondrial Bioenergetics by Esterase-Triggered COS/H₂S Donors.

ABSTRACT: Hydrogen sulfide (H₂S) is an important biological mediator, and synthetic H₂S donating molecules provide an important class of investigative tools for H₂S research. Here, we report esterase-activated H₂S donors that function by first releasing carbonyl sulfide (COS), which is rapidly converted to H₂S by the ubiquitous enzyme carbonic anhydrase (CA). We report the synthesis, self-immolative decomposition, and H₂S release profiles of the developed scaffolds. In addition, the developed esterase-triggered COS/H₂S donors exhibit higher levels of cytotoxicity than equivalent levels of Na₂S or the common H₂S donors GYY4137 and AP39. Using cellular bioenergetics measurements, we establish that the de

SUBMITTER: Steiger AK 

PROVIDER: S-EPMC6022832 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature