Could chronic Vardenafil administration influence the cardiovascular risk in men with type 2 diabetes mellitus?

ABSTRACT:

Introduction

Appropriate algorithms for the prediction of cardiovascular risk are strongly suggested in clinical practice, although still controversial. In type 2 diabetes mellitus (T2DM), the beneficial effect of phosphodiesterase (PDE)-5 inhibitors is demonstrated on endothelial function but not on the estimation of cardiovascular risk.

Aim

To study whether the chronic Vardenafil administration to men with T2DM influences variables correlated with the predicted long-term cardiovascular risk calculated by different validated algorithms.

Methods

Per-protocol analysis of a longitudinal, prospective, randomized, placebo-controlled, double-blind, investigator-started, clinical trial. 54 male patients affected by T2DM were assigned to study (26patients) and control-group

SUBMITTER: Santi D 

PROVIDER: S-EPMC6023114 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature