Genetic contributions to lupus nephritis in a multi-ethnic cohort of systemic lupus erythematous patients.

ABSTRACT:

Objective

African Americans, East Asians, and Hispanics with systemic lupus erythematous (SLE) are more likely to develop lupus nephritis (LN) than are SLE patients of European descent. The etiology of this difference is not clear, and this study was undertaken to investigate how genetic variants might explain this effect.

Methods

In this cross-sectional study, 1244 SLE patients from multiethnic case collections were genotyped for 817,810 single-nucleotide polymorphisms (SNPs) across the genome. Continental genetic ancestry was estimated utilizing the program ADMIXTURE. Gene-based testing and pathway analysis was performed within each ethnic group and meta-analyzed across ethnicities. We also performed candidate SNP association tests with SNPs previously established as risk

SUBMITTER: Lanata CM 

PROVIDER: S-EPMC6023154 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature