Genomic Influence in the Prevention of Cardiovascular Diseases with a Sterol-Based Treatment.

ABSTRACT: Raised serum cholesterol concentration is a well-established risk factor in cardiovascular disease. In addition, genetic load may have an indirect influence on cardiovascular risk. Plant-based sterol-supplemented foods are recommended to help reduce the serum low-density lipoprotein cholesterol level. The objective was to analyse the influence of different polymorphisms in hypercholesterolemia patients following a dietary treatment with plant sterols. A randomised double-blind cross-over controlled clinical trial was carried out in 45 people (25 women). Commercial milk, containing 2.24 g of sterols, was ingested daily during a 3-week period, and then the same amount of skim milk, without sterols, was consumed daily during the 3-week placebo phase. Both phases were separated by a washout pe

SUBMITTER: San Mauro Martin I 

PROVIDER: S-EPMC6023396 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature