Genetic Heterogeneity of SLC22 Family of Transporters in Drug Disposition.

ABSTRACT: An important aspect of modern medicine is its orientation to achieve more personalized pharmacological treatments. In this context, transporters involved in drug disposition have gained well-justified attention. Owing to its broad spectrum of substrate specificity, including endogenous compounds and xenobiotics, and its strategical expression in organs accounting for drug disposition, such as intestine, liver and kidney, the SLC22 family of transporters plays an important role in physiology, pharmacology and toxicology. Among these carriers are plasma membrane transporters for organic cations (OCTs) and anions (OATs) with a marked overlap in substrate specificity. These two major clades of SLC22 proteins share a similar membrane topology but differ in their degree of genetic variability. M

SUBMITTER: Lozano E 

PROVIDER: S-EPMC6023491 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature