DNA methylation in adults and during development of the self-fertilizing mangrove rivulus, Kryptolebias marmoratus.

ABSTRACT: In addition to genetic variation, epigenetic mechanisms such as DNA methylation might make important contributions to heritable phenotypic diversity in populations. However, it is often difficult to disentangle the contributions of genetic and epigenetic variation to phenotypic diversity. Here, we investigated global DNA methylation and mRNA expression of the methylation-associated enzymes during embryonic development and in adult tissues of one natural isogenic lineage of mangrove rivulus fish, Kryptolebias marmoratus. Being the best-known self-fertilizing hermaphroditic vertebrate affords the opportunity to work with genetically identical individuals to examine, explicitly, the phenotypic effects of epigenetic variance. Using the LUminometric Methylation Assay (LUMA), we described

SUBMITTER: Fellous A 

PROVIDER: S-EPMC6024129 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature