The use of Centiloids for applying [¹¹C]PiB classification cutoffs across region-of-interest delineation methods.

ABSTRACT:

Introduction

Centiloid standardization was developed to establish a quantitative outcome measure of amyloid burden that could accommodate the integration of different amyloid positron emission tomography radiotracers or different methods of quantifying the same tracer. The goal of this study was to examine the use of Centiloids for establishing amyloid classification cutoffs for differing region-of-interest (ROI) delineation schemes.

Methods

Using ROIs from hand-drawn delineation in native space as the gold standard, we compared standard uptake value ratios obtained from the 6 hand-drawn ROIs that determine amyloid-positivity classification with standard uptake value ratio obtained from 3 different automated techniques (FreeSurfer, Statistical Parametric Mapping, and superim

SUBMITTER: Tudorascu DL 

PROVIDER: S-EPMC6024172 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature