The rational design of specific SOD1 inhibitors via copper coordination and their application in ROS signaling research.

ABSTRACT: Efficient methods for the regulation of intracellular O₂˙^- and H₂O₂ levels, without altering intracellular processes, are urgently required for the rapidly growing interest in ROS signaling, as ROS signaling has been confirmed to be involved in a series of basic cellular processes including proliferation, differentiation, growth and migration. Intracellular H₂O₂ is formed mainly via the catalytic dismutation of O₂˙^- by SODs including SOD1, SOD2 and SOD3. Thus, the intracellular levels of O₂˙^- and H₂O₂ can directly be controlled through regulating SOD1 activity. Here, based on the active site structure and catalytic mechanism of SOD1, we developed a new

SUBMITTER: Dong X 

PROVIDER: S-EPMC6024207 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature