Chronic kidney disease, worsening renal function and outcomes in a heart failure community setting: A UK national study.

ABSTRACT:

Background

Routine heart failure (HF) monitoring and management is in the community but the natural course of worsening renal function (WRF) and its influence on HF prognosis is unknown. We investigated the influence of routinely monitored renal decline and related comorbidities on imminent hospitalisation and death in the HF community population.

Methods

A nested case-control study within an incident HF cohort (N = 50,114) with 12-years follow-up. WRF over 6-months before first hospitalisation and 12-months before death was defined by >20% reduction in estimated glomerular filtration rate (eGFR). Additive interactions between chronic kidney disease (CKD) and comorbidities were investigated.

Results

Prevalence of CKD (eGFR<60 ml/min/1.73m²) in the HF commun

SUBMITTER: Lawson CA 

PROVIDER: S-EPMC6024224 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature