Genetic predictors of testosterone and their associations with cardiovascular disease and risk factors: A Mendelian randomization investigation.

ABSTRACT:

Background

Testosterone supplementation has been linked to increased cardiovascular disease risk in some observational studies. The causal role of testosterone can be investigated using a Mendelian randomization approach.

Methods and results

We assessed genetic associations of variants in two gene regions (SHBG and JMJD1C) with several cardiovascular risk factors (lipids, adiponectin, blood pressure, anthropometric traits) plus male pattern baldness, including control outcomes and potential mediators. We assessed genetic associations with coronary artery disease (CAD) risk in the CARDIoGRAMplusC4D consortium (171,191 individuals including 60,801 cases), and associations with CAD and ischaemic stroke risk in the UK Biobank (367,643 individuals including 25,352 CAD cases and 3

SUBMITTER: Schooling CM 

PROVIDER: S-EPMC6024225 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature