Does intensified chemotherapy increase survival outcomes of osteosarcoma patients? A meta-analysis.

ABSTRACT:

Study design

Meta-analysis.

Background

Although some new insights have been offered for clinical and scientific relevance, minor progress has been made in osteosarcoma treatment after a dramatic survival improvement in the late 1980s with the addition of chemotherapy to surgery. Intensified chemotherapy strategies have been suggested to increase the survival rate of patients with osteosarcoma. We performed this study to access whether intensified chemotherapy strategiesincreased survival outcomes of osteosarcoma patients compared with conventional chemotherapy strategies.

Methods

MEDLINE/PubMed, EMBASE, BIOSIS Previews, and Cochrane Library were searched from database set up to October2016. Randomized controlled trials (RCTs) and comparative clinical trials (CCTs) on

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC6024259 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature