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Self-transformation and structural reconfiguration in coacervate-based protocells.

ABSTRACT: A functionalized small-molecule dipeptide capable of structural adaptation is used to prepare coacervate-based protocells that exhibit a pH-triggered process of self-transformation and structural reconfiguration. Polymer-dipeptide coacervate micro-droplets are prepared at pH 8.5 from aqueous mixtures of poly(diallyldimethylammonium chloride) and deprotonated N-(fluorenyl-9-methoxycarbonyl)-d-Ala-d-Ala, and transform into discrete aster-like micro-architectures by controlled lowering of the pH to 4.5. Reconfiguration of the micro-droplets results in entanglement and formation of an interpenetrating fibrous network that subsequently develops into a polymer-containing dipeptide hydrogel. Our results provide a step towards the assembly of synthetic protocells exhibiting rudimentary aspects of metamorphosis, and should offer a new approach to the design and construction of soft reconfigurable chemical micro-ensembles.

SUBMITTER: Krishna Kumar R

PROVIDER: S-EPMC6024302 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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Self-transformation and structural reconfiguration in coacervate-based protocells.

Krishna Kumar Ravinash R Harniman Robert L RL Patil Avinash J AJ Mann Stephen S

Chemical science 20160525 9

A functionalized small-molecule dipeptide capable of structural adaptation is used to prepare coacervate-based protocells that exhibit a pH-triggered process of self-transformation and structural reconfiguration. Polymer-dipeptide coacervate micro-droplets are prepared at pH 8.5 from aqueous mixtures of poly(diallyldimethylammonium chloride) and deprotonated <i>N</i>-(fluorenyl-9-methoxycarbonyl)-d-Ala-d-Ala, and transform into discrete aster-like micro-architectures by controlled lowering of th ...[more]

PMID: 30034729

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