Impact of gut colonization with butyrate-producing microbiota on respiratory viral infection following allo-HCT.

ABSTRACT: Respiratory viral infections are frequent in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HCT) and can potentially progress to lower respiratory tract infection (LRTI). The intestinal microbiota contributes to resistance against viral and bacterial pathogens in the lung. However, whether intestinal microbiota composition and associated changes in microbe-derived metabolites contribute to the risk of LRTI following upper respiratory tract viral infection remains unexplored in the setting of allo-HCT. Fecal samples from 360 allo-HCT patients were collected at the time of stem cell engraftment and subjected to deep, 16S ribosomal RNA gene sequencing to determine microbiota composition, and short-chain fatty acid levels were determined in a nested subset of feca

SUBMITTER: Haak BW 

PROVIDER: S-EPMC6024637 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature