Saracatinib Inhibits Middle East Respiratory Syndrome-Coronavirus Replication In Vitro.

ABSTRACT: The Middle East respiratory syndrome-coronavirus (MERS-CoV), first identified in Saudi Arabia, is an emerging zoonotic pathogen that causes severe acute respiratory illness in humans with a high fatality rate. Since its emergence, MERS-CoV continues to spread to countries outside of the Arabian Peninsula and gives rise to sporadic human infections following the entry of infected individuals to other countries, which can precipitate outbreaks similar to the one that occurred in South Korea in 2015. Current therapeutics against MERS-CoV infection have primarily been adapted from previous drugs used for the treatment of severe acute respiratory syndrome. In search of new potential drug candidates, we screened a library composed of 2334 clinically approved drugs and pharmacologically active co

SUBMITTER: Shin JS 

PROVIDER: S-EPMC6024778 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature