Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species.

ABSTRACT:

Background

DNA methylation is one of the main epigenetic mechanisms for the regulation of gene expression in eukaryotes. In the standard model, methylation in gene promoters has received the most attention since it is generally associated with transcriptional silencing. Nevertheless, recent studies in human tissues reveal that methylation of the region downstream of the transcription start site is highly informative of gene expression. Also, in some cell types and specific genes it has been found that methylation of the first intron, a gene feature typically rich in enhancers, is linked with gene expression. However, a genome-wide, tissue-independent, systematic comparative analysis of the relationship between DNA methylation in the first intron and gene expression across vertebrat

SUBMITTER: Anastasiadi D 

PROVIDER: S-EPMC6025724 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature