Resistance of HIV-infected macrophages to CD8⁺ T lymphocyte-mediated killing drives activation of the immune system.

ABSTRACT: CD4⁺ T lymphocytes are the principal target of human immunodeficiency virus (HIV), but infected macrophages also contribute to viral pathogenesis. The killing of infected cells by CD8⁺ cytotoxic T lymphocytes (CTLs) leads to control of viral replication. Here we found that the killing of macrophages by CTLs was impaired relative to the killing of CD4⁺ T cells by CTLs, and this resulted in inefficient suppression of HIV. The killing of macrophages depended on caspase-3 and granzyme B, whereas the rapid killing of CD4⁺ T cells was caspase independent and did not require granzyme B. Moreover, the impaired killing of macrophages was associated with prolonged effector cell-target cell contact time and higher expression of interferon-γ by CTLs, which i

SUBMITTER: Clayton KL 

PROVIDER: S-EPMC6025741 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature