Open chromatin dynamics reveals stage-specific transcriptional networks in hiPSC-based neurodevelopmental model.

ABSTRACT: Chromatin accessibility to transcription factors (TFs) strongly influences gene transcription and cell differentiation. However, a mechanistic understanding of the transcriptional control during the neuronal differentiation of human induced pluripotent stem cells (hiPSCs), a promising cellular model for mental disorders, remains elusive. Here, we carried out additional analyses on our recently published open chromatin regions (OCRs) profiling at different stages of hiPSC neuronal differentiation. We found that the dynamic changes of OCR during neuronal differentiation highlighted cell stage-specific gene networks, and the chromatin accessibility at the core promoter region of a gene correlates with the corresponding transcript abundance. Within the cell stage-specific OCRs, we identified t

SUBMITTER: Zhang S 

PROVIDER: S-EPMC6025752 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature