A retrospective study of concurrent chemoradiotherapy plus S-1 adjuvant chemotherapy on curative effect for treatment of patients with N3 stage nasopharyngeal carcinoma.

ABSTRACT:

Introduction

The purpose of this study was to analyze the efficacy and safety of concurrent chemoradiotherapy plus S-1 adjuvant chemotherapy for N3 stage nasopharyngeal carcinoma (NPC).

Methods

This study included 44 N3 stage NPC patients treated with concurrent chemoradiotherapy plus S-1 adjuvant chemotherapy. The intensity-modulated radiation therapy doses were planning target volume (PTV) 70-72 Gy for gross disease in the nasopharynx and 66-70 Gy for positive lymph nodes. The doses for high-risk- and low-risk region PTV were 60-62 and 54-56 Gy in 31-33 fractions. All patients received a concurrent chemotherapy program consisting of cisplatin 100 mg/m², day 1, and the cycle repetition was every 21 days. The adjuvant chemotherapy program consisted of 4 cycles of

SUBMITTER: Zhang S 

PROVIDER: S-EPMC6025766 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature