Tracheal diverticula in advanced cystic fibrosis: Prevalence, features, and outcomes after lung transplantation.

ABSTRACT:

Background

Tracheal diverticula (TD) are rare anomalies that may harbor infected secretions, posing potential risk to patients with lung disease. In an end-stage cystic fibrosis (CF) cohort, we describe the characteristics and associated post-lung transplant (LTx) outcomes of TD.

Methods

Pre-transplant computed tomography (CT)'s were reviewed in CF patients undergoing LTx. TD were characterized radiographically and on autopsy when available. Pre-transplant clinical variables and post-transplant outcomes were compared by TD status.

Results

Of 93 patients, 35 (37.6%) had TD. 58% of TD had fat-stranding, and post-mortem TD examinations revealed histology carrying intense submucosal inflammation, and purulent contents that cultured identical species to sputum. There was n

SUBMITTER: Kapnadak SG 

PROVIDER: S-EPMC6025899 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature