Pharmacological induction of hypoxia-inducible transcription factor ARNT attenuates chronic kidney failure.

ABSTRACT: Progression of chronic kidney disease associated with progressive fibrosis and impaired tubular epithelial regeneration is still an unmet biomedical challenge because, once chronic lesions have manifested, no effective therapies are available as of yet for clinical use. Prompted by various studies across multiple organs demonstrating that preconditioning regimens to induce endogenous regenerative mechanisms protect various organs from later incurring acute injuries, we here aimed to gain insights into the molecular mechanisms underlying successful protection and to explore whether such pathways could be utilized to inhibit progression of chronic organ injury. We identified a protective mechanism controlled by the transcription factor ARNT that effectively inhibits progression of chronic ki

SUBMITTER: Tampe B 

PROVIDER: S-EPMC6025987 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature