An estrogen-related lifestyle score is associated with risk of postmenopausal breast cancer in the PLCO cohort.

ABSTRACT:

Purpose

Healthy or unhealthy lifestyle behaviors are often adopted together. We aimed to investigate the combined effect of estrogen-related lifestyle factors on postmenopausal breast cancer risk.

Methods

Data from 27,153 women enrolled in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial were used. We created an estrogen-related lifestyle score (ERLS) by incorporating a previously developed measure of estrogenic diet, alcohol intake, body mass index (BMI), and physical activity. The scores ranged from 0 to 6 with alcohol and BMI accounting for higher weights than the other factors. To evaluate the preventive possibilities of a low estrogen-related lifestyle and to be consistent with other published lifestyle scores, higher scores were set to correspond with

SUBMITTER: Guinter MA 

PROVIDER: S-EPMC6026043 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature