Opposing Roles of Estradiol and Testosterone on Stress-Induced Visceral Hypersensitivity in Rats.

ABSTRACT: Chronic stress produces maladaptive pain responses, manifested as alterations in pain processing and exacerbation of chronic pain conditions including irritable bowel syndrome. Female predominance, especially during reproductive years, strongly suggests a role of gonadal hormones. However, gonadal hormone modulation of stress-induced pain hypersensitivity is not well understood. In the present study, we tested the hypothesis that estradiol is pronociceptive and testosterone is antinociceptive in a model of stress-induced visceral hypersensitivity (SIVH) in rats by recording the visceromotor response to colorectal distention after a 3-day forced swim (FS) stress paradigm. FS induced visceral hypersensitivity that persisted at least 2 weeks in female, but only 2 days in male rats. Ovariectom

SUBMITTER: Ji Y 

PROVIDER: S-EPMC6026052 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature