A naturally occurring antiviral ribonucleotide encoded by the human genome.

ABSTRACT: Viral infections continue to represent major challenges to public health, and an enhanced mechanistic understanding of the processes that contribute to viral life cycles is necessary for the development of new therapeutic strategies ¹ . Viperin, a member of the radical S-adenosyl-L-methionine (SAM) superfamily of enzymes, is an interferon-inducible protein implicated in the inhibition of replication of a broad range of RNA and DNA viruses, including dengue virus, West Nile virus, hepatitis C virus, influenza A virus, rabies virus ² and HIV^3,4. Viperin has been suggested to elicit these broad antiviral activities through interactions with a large number of functionally unrelated host and viral proteins^3,4. Here we demonstrate that viperin catalyse

SUBMITTER: Gizzi AS 

PROVIDER: S-EPMC6026066 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature