Perinatally acquired HIV infection accelerates epigenetic aging in South African adolescents.

ABSTRACT:

Objective

Recent studies demonstrate that infection with the HIV-1 is associated with accelerated aging effects in adults according to a highly accurate epigenetic biomarker of aging known as epigenetic clock. However, it is not yet known whether epigenetic age acceleration occurs as early as adolescence in perinatally HIV-infected (PHIV+) youth.

Design

Observational study of PHIV and HIV-uninfected adolescents enrolled in the Cape Town Adolescent Antiretroviral Cohort Study.

Methods

The Illumina EPIC array was used to generate blood DNA methylation data from 204 PHIV and 44 age-matched, uninfected (HIV-) adolescents aged 9-12 years old. The epigenetic clock software and method was used to estimate two measures of epigenetic age acceleration. Each participant complete

SUBMITTER: Horvath S 

PROVIDER: S-EPMC6026068 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature