Genes Encoding GABA-β and HT1D Receptors in Bipolar I (Manic Phase) Patients.

ABSTRACT:

Introduction

According to the cumulative evidence, genes encoding GABA receptors inhibit neurotransmitters in CNS and are intricately involved in the pathogenesis of mood disorders. Based on this hypothesis, these genes may be expressed in bipolar patients. As a result, we evaluated the gene expressions of GABA-β3 and HT1D receptors to assess their associations with bipolar mood disorder.

Methods

In this study, 22 patients with bipolar I disorder (single manic episode) and 22 healthy individuals were enrolled. All participants were older than 15 years and had referred to Farshchian Hospital, Hamadan, Iran. They were diagnosed based on DSM IV-TR criteria and young mania rating scale in order to determine the severity of mania by a psychiatrist as bipolar Type 1 disorder in ma

SUBMITTER: Moradi M 

PROVIDER: S-EPMC6026092 | biostudies-literature | 2018 Mar-Apr

REPOSITORIES: biostudies-literature