Lobar Emphysema Distribution Is Associated With 5-Year Radiological Disease Progression.

ABSTRACT:

Background

Emphysema has considerable variability in its regional distribution. Craniocaudal emphysema distribution is an important predictor of the response to lung volume reduction. However, there is little consensus regarding how to define upper lobe-predominant and lower lobe-predominant emphysema subtypes. Consequently, the clinical and genetic associations with these subtypes are poorly characterized.

Methods

We sought to identify subgroups characterized by upper-lobe or lower-lobe emphysema predominance and comparable amounts of total emphysema by analyzing data from 9,210 smokers without alpha-1-antitrypsin deficiency in the Genetic Epidemiology of COPD (COPDGene) cohort. CT densitometric emphysema was measured in each lung lobe. Random forest clustering was applied

SUBMITTER: Boueiz A 

PROVIDER: S-EPMC6026264 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature