Improved Early Detection of Sepsis in the ED With a Novel Monocyte Distribution Width Biomarker.

ABSTRACT:

Background

Sepsis most often presents to the ED, and delayed detection is harmful. WBC count is often used to detect sepsis, but changes in WBC count size also correspond to sepsis. We sought to determine if volume increases of circulating immune cells add value to the WBC count for early sepsis detection in the ED.

Methods

A blinded, prospective cohort study was conducted in two different ED populations within a large academic hospital.

Results

Neutrophil and monocyte volume parameters were measured in conjunction with routine CBC testing on a UniCel DxH 800 analyzer at the time of ED admission and were evaluated for the detection of sepsis. There were 1,320 subjects in the ED consecutively enrolled and categorized as control subjects (n = 879) and those with systemi

SUBMITTER: Crouser ED 

PROVIDER: S-EPMC6026271 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature