Chemical transformation and target preparation of saponins in stems and leaves of Panax notoginseng.

ABSTRACT:

Background

Notoginsenoside Ft1 is a promising potential candidate for cardiovascular and cancer disease therapy owing to its positive pharmacological activities. However, the yield of Ft1 is ultralow utilizing reported methods. Herein, an acid hydrolyzing strategy was implemented in the acquirement of rare notoginsenoside Ft1.

Methods

Chemical profiles were identified by ultraperformance liquid chromatography coupled with quadruple-time-of-flight and electrospray ionization mass spectrometry (UPLC-Q/TOF-ESI-MS). The acid hydrolyzing dynamic changes of chemical compositions and the possible transformation pathways of saponins were monitored by ultrahigh-performance LC coupled with tandem MS (UHPLC-MS/MS).

Results and conclusion

Notoginsenoside Ft1 was epimerized from n

SUBMITTER: Wang RF 

PROVIDER: S-EPMC6026369 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature