A network of epigenomic and transcriptional cooperation encompassing an epigenomic master regulator in cancer.

ABSTRACT: Coordinated experiments focused on transcriptional responses and chromatin states are well-equipped to capture different epigenomic and transcriptomic levels governing the circuitry of a regulatory network. We propose a workflow for the genome-wide identification of epigenomic and transcriptional cooperation to elucidate transcriptional networks in cancer. Gene promoter annotation in combination with network analysis and sequence-resolution of enriched transcriptional motifs in epigenomic data reveals transcription factor families that act synergistically with epigenomic master regulators. By investigating complementary omics levels, a close teamwork of the transcriptional and epigenomic machinery was discovered. The discovered network is tightly connected and surrounds the histone lysine

SUBMITTER: Wilson S 

PROVIDER: S-EPMC6026491 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature