An update of the recombinant protein expression systems of Cyanovirin-N and challenges of preclinical development.

ABSTRACT: Introduction: Human immunodeficiency virus (HIV) is a debilitating challenge and concern worldwide. Accessibility to highly active antiretroviral drugs is little or none for developing countries. Production of cost-effective microbicides to prevent the infection with HIV is a requirement. Cyanovirin-N (CVN) is known as a promising cyanobacterial lectin, capable of inhibiting the HIV cell entry in a highly specific manner. Methods: This review article presents an overview of attempts conducted on different expression systems for the recombinant production of CVN. We have also assessed the potential of the final recombinant product, as an effective anti-HIV microbicide, comparing prokaryotic and eukaryotic expression systems. Results: Artificial prod

SUBMITTER: Lotfi H 

PROVIDER: S-EPMC6026528 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature