Fatty acid binding protein-4 is associated with disability in multiple sclerosis patients.

ABSTRACT:

Background

Increased adiposity is a risk factor for multiple sclerosis (MS) and is associated with increased disability scores. Adipokines may mediate the effects of adiposity on MS disease course.

Objective

The objective of this study is to examine the association between the adipokines (leptin and fatty acid binding protein-4, FABP4) and clinical course in individuals with MS.

Methods

Subjects (18-65 years) with relapsing-remitting MS or clinically isolated syndrome and <10 year disease duration were selected from a longitudinal clinical study. Cross-sectional and longitudinal models assessed the relationship between two adipokines (leptin and FABP4) and disease severity in women and men, adjusting for age, disease duration and disease type, Vitamin D level, testost

SUBMITTER: Bove R 

PROVIDER: S-EPMC6026579 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature