Raspberry alleviates obesity-induced inflammation and insulin resistance in skeletal muscle through activation of AMP-activated protein kinase (AMPK) α1.

ABSTRACT:

Objective

Through dynamic means, etiological factors, including chronic inflammation and insulin resistance have the potential to perpetuate metabolic incidences such as type 2 diabetes and obesity. Abatement of such syndromes can be achieved by complex mechanisms initiated through bioactive compounds such as polyphenols derived from fruits. Using a whole-fruit approach, the effects of dietary red raspberry, which is rich in polyphenols, on inflammatory responses and insulin resistance in the skeletal muscles of Mus musculus were studied along with the potential role of AMP-activated protein kinase (AMPK) to act as a key mediator.

Subjects

Wild-type (WT) mice and mice deficient in the catalytic subunit (α1) of AMPK (AMPKα1^-/-) were fed with a high-fat d

SUBMITTER: Zhao L 

PROVIDER: S-EPMC6026595 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature