Development of Methods for the Mapping of Utilities Using Mixture Models: Mapping the AQLQ-S to the EQ-5D-5L and the HUI3 in Patients with Asthma.

ABSTRACT:

Background

Studies have shown that methods based on mixture models work well when mapping clinical to preference-based methods.

Objectives

To develop these methods in different ways and to compare performance in a case study.

Methods

Data from 856 patients with asthma allowed mapping between the Asthma Quality of Life Questionnaire and both the five-level EuroQol five-dimensional questionnaire (EQ-5D-5L) and the health utilities index mark 3 (HUI3). Adjusted limited dependent variable mixture models and beta-based mixture models were estimated. Optional inclusion of the gap between full health and the next value as well as a mass point at the next feasible value were explored.

Results

In all cases, model specifications formally modeling the gap between full hea

SUBMITTER: Gray LA 

PROVIDER: S-EPMC6026598 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature