DLG-1 is a MAGUK similar to SAP97 and is required for adherens junction formation.

ABSTRACT: Cellular junctions are critical for intercellular communication and for the assembly of cells into tissues. Cell junctions often consist of tight junctions, which form a permeability barrier and prevent the diffusion of lipids and proteins between cell compartments, and adherens junctions, which control the adhesion of cells and link cortical actin filaments to attachment sites on the plasma membrane. Proper tight junction formation and cell polarity require the function of membrane-associated guanylate kinases (MAGUKs) that contain the PDZ protein-protein interaction domain. In contrast, less is known about how adherens junctions are assembled. Here we describe how the PDZ-containing protein DLG-1 is required for the proper formation and function of adherens junctions in Caenorhabditis el

SUBMITTER: Firestein BL 

PROVIDER: S-EPMC60268 | biostudies-literature | 2001 Nov

REPOSITORIES: biostudies-literature