Disrupted engagement of networks supporting hot and cold cognition in remitted major depressive disorder.

ABSTRACT:

Background

Major depressive disorder (MDD) is characterized by dysfunction in cognitive and emotional systems. However, the neural network correlates of cognitive control (cold cognition) and emotion processing (hot cognition) during the remitted state of MDD (rMDD) remain unclear and not fully probed, which has important implications for identifying intermediate phenotypes of depression risk.

Methods

43 young adults with rMDD and 33 healthy controls (HCs) underwent fMRI while completing separate tasks of cold cognition (Parametric Go/No-Go test) and hot cognition (Facial Emotion Processing Test). Two 2 group (rMDD, HC) × 2 event (sad/fearful faces, correct rejections) factorial models of activation were calculated in SPM8. Functional activation was evaluated in the salience

SUBMITTER: Stange JP 

PROVIDER: S-EPMC6026853 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature