Development of White Matter Circuitry in Infants With Fragile X Syndrome.

ABSTRACT:

Importance

Fragile X syndrome (FXS) is a genetic neurodevelopmental disorder and the most common inherited cause of intellectual disability in males. However, there are no published data on brain development in children with FXS during infancy.

Objective

To characterize the development of white matter at ages 6, 12, and 24 months in infants with FXS compared with that of typically developing controls.

Design, setting, and participants

Longitudinal behavioral and brain imaging data were collected at 1 or more time points from 27 infants with FXS and 73 typically developing controls between August 1, 2008, and June 14, 2016, at 2 academic medical centers. Infants in the control group had no first- or second-degree relatives with intellectual or psychiatric disorders, in

SUBMITTER: Swanson MR 

PROVIDER: S-EPMC6026861 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature