Antiretroviral therapy for pregnant women living with HIV or hepatitis B: a systematic review and meta-analysis.

ABSTRACT:

Objective

To assess the impact of various antiretroviral/antiviral regimens in pregnant women living with HIV or hepatitis B virus (HBV).

Design

We performed random effects meta-analysis for HIV-related outcomes and network meta-analysis for HBV outcomes, and used the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework to assess quality separately for each outcome.

Data sources

Embase and Medline to February 2017.

Eligibility criteria

For maternal outcomes, we considered randomised controlled trials (RCTs) comparing tenofovir-based regimens with those with alternative nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs). For child outcomes, we included RCTs and comparative observational studies of tenofovir-based regime

SUBMITTER: Siemieniuk RA 

PROVIDER: S-EPMC6027063 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature