Non-Coding RNA as Novel Players in the Pathophysiology of Schizophrenia.

ABSTRACT: Schizophrenia is associated with diverse changes in the brain's transcriptome and proteome. Underlying these changes is the complex dysregulation of gene expression and protein production that varies both spatially across brain regions and temporally with the progression of the illness. The growing body of literature showing changes in non-coding RNA in individuals with schizophrenia offers new insights into the mechanisms causing this dysregulation. A large number of studies have reported that the expression of microRNA (miRNA) is altered in the brains of individuals with schizophrenia. This evidence is complemented by findings that single nucleotide polymorphisms (SNPs) in miRNA host gene sequences can confer an increased risk of developing the disorder. Additionally, recent evidence sug

SUBMITTER: Gibbons A 

PROVIDER: S-EPMC6027250 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature